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These include, for example, transitions and trajectories with youngpeople in crisis about their identity and future prospects, mid-life gendered patterns of work and fam-ily, and older people in social and biological decline. Microscopi-cally, in addition to severe neuronal loss and gliosis in thedescribed regions, the pathognomonic finding is the Pickbody, which is the cytoplasmic inclusion found in neuronsin the frontal and temporal cortices, as well as in the lim-bic and paralimbic cortices and temporal lobe, especiallythe granule cell layer of the hippocampus. Each phase of research has unique chal-lenges and requires different skill sets. Esti-mated energy expenditure can be calculated in meta-bolic equivalents (METS), a ratio of the metabolicrate during activity to resting metabolic rate: vigor-ous work-related activities (lifting heavy loads, heavyconstruction) 8.0, jogging, running, cross-countryskiing 8.0, swimming, other vigorous water activities6.0, less strenuous home maintenance, gardening 5.0,and bowling or golf 3.5. (D) At 30 weeks, this infant is crawling aroundand on the go.

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